Chester W. Price, Ph.D.
Food Science and Technology
Microbiology & Molecular Genetics
Food Science (1984-2008)
Ph.D. University of California, Davis 1976
Professor Price and his lab colleagues used a molecular genetic approach to investigate the general stress response in bacteria, examining a model organism with relevance to human pathogens.
In the Bacillus subtilis model and related Gram positive bacteria, the σB transcription factor is activated by diverse environmental and nutritional stresses to increase the expression of more than 150 genes, the products of which provide broad protection against future challenges. Research was aimed at understanding this response, including the sensors that detect the different stresses, the signal transduction network that conveys this information to σB, and the physiological role of the gene products under σB control.
The basic signaling mechanism that emerged is now recognized as widespread among bacteria, where it has been adapted to different signaling tasks. Notably, essentially the same signaling pathway is found among Gram positive human pathogens related to the Bacillus subtilis model, including Listeria monocytogenes, Bacillus cereus, and Staphylococcus aureus, and the general stress response it controls contributes to their growth and survival in the natural environment, in foods, and in pathogenic interactions.
Price CW, Fawcett P, Cérémonie H, Su N, Murphy CK, Youngman P. 2001. Genome-wide analysis of the general stress response in Bacillus subtilis. Mol Microbiol 41:757-774. PMID: 11532142.
Vijay K, Brody MS, Fredlund E, Price CW. 2000. A PP2C phosphatase containing a PAS domain is required to convey signals of energy stress to the σB transcription factor of Bacillus subtilis. Mol Microbiol 35:180-188. PMID: 10632888
Yang X, Kang CM, Brody MS, Price CW. 1996. Opposing pairs of serine protein kinases and phosphatases transmit signals of environmental stress to activate a bacterial transcription factor. Genes Dev 10:2265-2275. PMID: 8824586
Boylan SA, Redfield AR, Brody MS, Price CW. 1993. Stress-induced activation of the σB transcription factor of Bacillus subtilis. J Bacteriol 175:7931-7937. PMID: 8253681
Price CW, Fuson GB, Phaff HJ. 1978. Genome comparison in yeast systematics: delimitation of species within the general Schwanniomyces, Saccharomyces, Debaryomyces, and Pichia. Microbiol Rev 42:161-193. PMID: 379571
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