Ameer Taha, Ph.D.
Food Science and Technology
Ph.D., Pharmacology and Toxicology, University of Toronto, Toronto, Canada
M.S., Nutritional Sciences, University of Toronto, Toronto, Canada
My lab uses mass-spectrometry-based ‘omic’ methods to quantify oxidized lipids and lipid-like environmental toxins (such as pesticides and antibiotics) in the food supply, and to understand how they impact the brain. Currently, the lab is - 1) assessing the role of oxidized lipids present in processed food products on brain function, 2) investigating the role of maternal pesticide exposure on neurodevelopmental disorders such as autism, and 3) quantifying human exposure to antibiotics from farmed seafood. Ultimately, this research will inform on the critical levels of exposure that could alter brain development or vulnerability to neurodegenerative processes.
- Ramsden, C.E., Faurot, K.R., Zamora, D., Palsson, O.S., Macintosh, B.A., Gaylord, S., Taha, A.Y., Rapoport, S.I., Hibbeln, J.R., Davis, J.M., Mann, J.D. (2015). Targeted alterations in dietary n-3 and n-6 fatty acids improve life functioning and reduce psychological distress among chronic headache patients: secondary analysis of a randomized trial. Pain, Epub ahead of print.
- Blanchard, H.C., Taha, A.Y., Chang L, Chen M, Rapoport SI. Low-dose aspirin (acetylsalicylate) prevents increases in brain PGE2, 15-epi-lipoxin A4 and 8-isoprostane concentrations in 9 month-old HIV-1 transgenic rats, a model for HIV-1 associated neurocognitive disorders. (2015) Prostaglandins, Leukotreines and Essential Fatty Acids, Epub ahead of print.
- Taha, A.Y., Cheon, Y., Faurot, K.F., MacIntosh, B., Majchrazak-Hong, S., Mann, J.D., Hibbeln, J.R., Ringel, A., Ramsden, C.E. (2014). Dietary omega-6 fatty acid lowering increases bioavailability of omega-3 polyunsaturated fatty acids in human plasma lipid pools. Prostaglandins, Leukotreines and Essential Fatty Acids, 90(5):151-7.
- Taha, A.Y., Chang L, Chen M, Rapoport SI, Ramadan E. D2 like receptor activation does not initiate a brain docosahexaenoic signal in unanaesthetized rats. (2014) BMC Neuroscience, Oct 30;15:113. doi: 10.1186/1471-2202-15-113.
- Blanchard, H.C., Taha, A.Y., Cheon, Y., Kim, H.W., Turk, J., Rapoport, S.I. (2014). iPLA2β knockout mouse, a genetic model for progressive human motor disorders, develops age-related neuropathology model of Parkinson disease. Neurochem Res. 39(8):1522-32.
- Bondi C.O., Taha, A.Y., Tock, J.L., Totah, N.K., Cheon, Y., Torres, G.E., Rapoport, S.I., Moghaddam, B. (2014). Adolescent Behavior and Dopamine Availability Are Uniquely Sensitive to Dietary Omega-3 Fatty Acid Deficiency. Biological Psychiatry, 75(1):38-46.
- Keleshian, V.L., Kellom, M., Kim, H.W., Taha, A.Y., Cheon, Y., Igarashi, M., Rapoport, S.I., Rao, J.S. (2014). Fish oil supplementation of rats fed an adequate, alpha-linolenic acid containing, n-3 PUFA diet does not reduce pathological brain responses to NMDA, whereas n-3 PUFA deprivation worsens these responses. PLOS ONE. 9(5):e95318, 2014.
- Trepanier, M.O., Lim, J., Lai, T.K.Y., Cho, H.J., Domenichiello, A.F., Chen, C.T., Taha, A.Y., Bazinet, R.P., Burnham, W.M. (2014). Intraperitoneal administration of docosahexaenoic acid for 14 days increases serum unesterified DHA and seizure latency in the maximal pentylenetetrazole model. Epilepsy & Behavior, Volume 33, issue (April, 2014), p. 138-143.
- Taha, A.Y., Cheon Y., Ma, K., Rapoport, S.I., Rao, J.S. (2013). Altered fatty acid concentrations in prefrontal cortex of schizophorenic patients. Journal of Psychiatric Research, 45(5): 636-43.
- Taha, A.Y., Zahid, T., Epps, T., Burnham, W.M., Bazinet, R.P., Zhang, L. (2013). Selective reduction of excitatory hippocampal sharp waves by docosahexaenoic acid and its methyl ester analogue ex vivo. Brain Res, 1537: 9-17.
- Taha, A.Y., Trepanier, M.O., Ciobanu, F.A., Taha, N.M., Ahmed, M., Zeng, Q., Cheuk, W.I., Ip, B., Filo, E., Scott, B.W., Burnham, W.M., Bazinet, R.P. (2013). A minimum of 3 months of dietary fish oil supplementation is required to raise amygdaloid afterdischarge seizure thresholds in rats - implications for treating complex partial seizures. Epilepsy and Behavior, 27(1):49-58.