RESEARCH OBJECTIVES AND ACCOMPLISHMENTS
The lipid or fatty component is responsible for much of the beneficial sensory
attributes of food, yet the over-consumption of specific classes of fats is
implicated in the etiology of many human chronic diseases. Health organizations
have suggested that changing the fatty acid composition of human diets would
significantly decrease the susceptibility to diseases such as heart disease,
cancer and autoimmunity. Unfortunately, an understanding of the mechanisms
by which these beneficial effects act and even the physical means to implement
these changes on the typical Western diet are largely unknown. Research in
this laboratory seeks to develop the chemical, biochemical and nutritional
information needed, such that more precise estimates of benefits and risks
of modulating the lipid composition of foods can be developed.
The researchers in the laboratory examine the chemistry of fats in food and their
effects on the metabolism of animals that ingest them. Research is developing
the means to understand how individual human lipid metabolism responds to the
lipid composition of diets. Each person has slightly different responses to diet
based on their own genetics, metabolism and nutrition status. One of the goals
of the laboratory research is to understand the molecular basis of these differences,
how to recognize them and design food strategies to complement them. We are working
on analyses to allow individuals to monitor how their body reacts to various
foods and to modify their consumption to maintain good health. The laboratory
group is also seeking to understand how to improve foods and their abilities
to deliver improved health. The model being used of how to proceed is milk, which
evolved to make healthy mammals healthier. Milk is the only bio-material that
has evolved under the Darwinian selection pressure for the purpose of nourishing
growing mammals. Survival of offspring exerted a strong selective pressure on
the biochemical evolution of lactation. This process has led to the appearance
of new compositional properties of milk that promote health, strength and ultimately
survival. This evolutionary logic is the basis of the research program to discover
physical, functional and nutritional properties of milk components.
SELECTED PUBLICATIONS:
- Huang S-W, Satué-Gracia M.T., Frankel E.N. and German J.B.
(1999) Effect of lactoferrin on oxidative stability of corn oil emulsions
and liposomes. Journal of Agricultural and Food Chemistry 47(4): 1356–1361
- Donovan J.L., Bell J.R., Kasim-Karakas S., German J.B., Walzem R.L.,
Hansen R.J. and Waterhouse A.L. (1999) Catechin is present as metabolites
in human plasma after consumption of red wine. Journal of Nutrition
129(9): 1662–1668
- German B., Schiffrin E.J., Reniero R., Mollet B, Pfeifer A. and Neeser
J.-R. (1999) The development of functional foods: lessons from the gut.
Trends in Biotechnology 17(12): 492–499
- Bell J.R., Donovan J.L., Wong R., Waterhouse A.L., German J.B., Walzem
R.L. and Kasim-Karakas S.E. (2000) (+)-Catechin in human plasma after
ingestion of a single serving of reconstituted red wine. American Journal
of Clinical Nutrition 71(1): 103–108
- Roberts M., Geiger W. and German B. (2000) The revolution in microanalytic
chemistry: a macro-opportunity for clinical nutrition. American Journal
of Clinical Nutrition 71(2): 434-437
- German J.B. and Walzem R.L. (2000) The health benefits of wine. Annual
Review of Nutrition 20: 561–593
- Satué -Gracia M.T., Frankel E.N., Rangavajhyala N. and German
J.B. (2000) Lactoferrin in infant formulas: effect on oxidation. Journal
of Agricultural and Food Chemistry 48: 4984–4990
- Schramm
D.D., Wang J.F., Holt R.R., Ensunsa J.L., Gonsalves J.L., Lazarus
S.A., Schmitz H.H., German J.B. and Keen C.L. (2001). Chocolate
procyanidins decrease the leukotriene-prostacyclin ratio in humans
and human aortic endothelial cells.(Abstract) American
Journal of Clinical Nutrition 73(1): 36–40
- Watkins S.M. Lin, T.R. Davis R.M. Ching J.R. DePeters E.J. Halpern
G.M., Walzem R.L. and German J.B. (2001) Unique phospholipid metabolism
in mouse heart in response to dietary docosahexaenoic or alpha-linolenic
acids. Lipids 36(3): 247–254
- Stanton B., Watkins S., German J.B. and Lasley B. (2001) Interaction
of estrogen and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) with hepatic
fatty acid synthesis and metabolism of male chickens (Gallus domesticus).
Comparative Biochemistry and Physiology C Toxicology and Pharmacology
129(2): 137–150
- Watkins S.M., Hammock B.D., Newman J.W. and German J.B. (2001) Individual
metabolism should guide agriculture toward foods for improved health
and nutrition. American Journal of Clinical Nutrition 74(3): 283–286
- Watkins S.M. and German J.B. (2002) Metabolomics and biochemical profiling
in drug discovery and development Current Opinion in Molecular Therapeutics
4(3): 224–228
- Watkins, S.M., Reifsnyder P.R., Pan H.-J., German J.G. and Leiter E.H.
(2002) Lipid metabolome-wide effects of the PPARgamma agonist rosiglitazone.
Journal of Lipid Research 43(11): 1809–1817
- German J.B., Roberts M., Fay L. and Watkins S.M. (2002) Metabolomics
and individual metabolic assessment: the next great challenge for nutrition.
Journal of Nutrition 132(9): 2486–2487
- German J.B., Dillard C.J. and Ward R.F. (2002) Bioactive components
in milk. Current Opinion in Clinical Nutrition and Metabolic Care 5(6):
653–658
- Desiere F., German B, Watzke H., Pfeifer A. and Saguy S. (2002) Bioinformatics
and data knowledge: the frontiers for nutrition and foods. Trends in
Food Science & Technology 12: 215–229
- Berger A., Mutch D.M., German J.B., Roberts M.A. (2002) Dietary effects
of arachidonate-rich fungal oil and fish oil on murine hepatic and hippocampal
gene expression. Lipids in Health and Disease 1:2 (21 October 2002)
- Mensink R.P., Aro A., Den Hond E. German, J.B., Griffin, B.A., Ten
Meer, H.U., Mutanen, M., Pannemans, D. and Stahl, W. (2003) PASSCLAIM
- Diet-related cardiovascular disease. European Journal of Nutrition
42(Mar.) Suppl 1: I6–I27
- German J.B., Roberts M.A. and Watkins S.M. (2003) Genomics and metabolomics
as markers for the interaction of diet and health: lessons from lipids.
Journal of Nutrition 133(6) 2078S–2083S
- Ward R.E. and German J.B. (2003) Zoonutrients and health. Food Technology 57(3):
30–36
- Ward R.E. and German J.B.
(2004) Understanding milk's bioactive components: A goal for the
genomics toolbox. Journal of Nutrition 134(4): 962S–967S
- Vega-Lopez S., Kaul N., Devaraj S., Cai R.Y., German B. and Jialal
I. (2004) Supplementation with omega3 polyunsaturated fatty acids and
all-rac alpha-tocopherol alone and in combination failed to exert an
anti-inflammatory effect in human volunteers. Metabolism 53(2): 236–240
- Ward R.E., Watzke H.J., Jiménez-Flores R. and German J.B. (2004).
Bioguided processing: A paradigm change in food production. Food Technology
58(5): 44–48
- Neeser J-R and German JB, editors (2004) Bioprocess and Biotechnology
for Functional Foods and Nutraceuticals. Marcel Dekker, New York, NY
- German J.B. and Dillard C.J. (2004) Saturated fats: what dietary intake?
American Journal of Clinical Nutrition 80(3): 550–559
- German J.B. and Watkins S.M. (2004) Metabolic assessment–a key
to nutritional strategies for health. Trends in food Science & Technology
15: 541–549
- German B and Young V.R. (2004) Nutrition and genomics. In: Metabolic
Issues of Clinical Nutrition. Allison S.P. and Go VLW eds. Karger AG,
Basel, Switzerland, pp. 243–263
- German J.B., Bauman D.E., Burrin D.G., Failla M.L., Freake H.C., King
J.C., Klein S., Milner J.A., Pelto G.H. Rasmussen K.M. and Zeisel. S.H.
2004. Metabolomics in the opening decade of the 21st century: Building
the roads to individualized health. The Journal of Nutrition 134: 2729–2732
- German J.B. and Watzke H.J. 2004. Personalizing foods for health and
delight. Comprehensive Reviews in Food Science and Food Safety 3(4):
145–151